Contact information
講座・京都大学大学院　医学研究科
クリニカルバイオリソース研究開発講座
〒606-8501 京都市左京区吉田下阿達町46-29
医薬系総合研究棟503号室
TEL:075-752-7512 FAX:075-752-7513
(学内専用内線:16-89515）
E-mail・jumpeko@kuhp.kyoto-u.ac.jp

EDUCATION

PROFESSIONAL EXPERIENCE

RESEARCH FIELD

３次元初代細胞培養, 消化管運動, BMP/SMADシグナル

REFERENCE

1. Onuma K, Sato Y, Okuyama H, Uematsu H, Homma K, Ohue M, Kondo J, Inoue M Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma J Pathol. 2021 Jun 22. doi: 10.1002/path.5748.
2. Tanaka M, Kondo J, Kaneko K, Endo H, Onuma K, Coppo R, Masuda M, Kamiura S, Yoshino K, Ueda Y, Kakeya H, Kimura T, Inoue M Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix Hum Cell. 2021 May;34(3):889-900.
3. Endo H, Kondo J, Onuma K, Ohue M, Inoue M
   A small subset of Wnt‐activated cells is an initiator of regrowth in colorectal cancer organoids after irradiation Cancer Sci. First published: 11 October 2020
4. Kondo J*, Huh WJ, Franklin JL, Heinrich MC, Rubin BP, Coffey RJ (*corresponding author)
   A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin J Pathol. First published: 17 September 2020
5. Arita T, Kondo J*, Kaneko Y, Tsutsumi M, Kanemaru M, Matsui M, Arakawa Y, Katoh N, Inoue M, Asai J (*co-first and co-corresponding author)
   Novel ex vivo disease model for extramammary Paget's disease using the cancer tissue-originated spheroid method J Dermatol Sci. 2020 Aug 5;S0923-1811(20)30237-1.
6. Kubota S, Tanaka M, Endo H, Ito Y, Onume K, Ueda Y, Mikura S, Yoshino K, Kimura T, Kondo J, Inoue M.
   Dedifferentiation of neuroendocrine carcinoma of the uterine cervix in hypoxia BBRC. 2020 Jan 30, 9 [epub ahead of print]
7. Ideo H, Kondo J, Nomura T, Nonomura N, Inoue M, Amano J
   Study of glycosylation of prostate-specific antigen secreted by cancer tissue-originated spheroids reveals new candidates for prostate cancer detection Sci Rep. 2020 Feb 17;10, Article number: 2708
8. Hagihara T, Kondo J*, Endo H, Ohue M, Sakai Y, Inoue M. (*corresponding author)
   Hydrodynamic stress stimulates growth of cell clusters via the ANXA1/PI3K/AKT axis in colorectal cancer Sci Rep. 2019 Dec 27, 9, Article number: 20027
9. Tian J, Teuscher K, Aho ER, Alvarado JR, Mills JJ, Meyers KM, Gogliotti RD, Han C, Macdonald JD, Sai J, Shaw JG, Sensintaffar JL, Zhao B, Rietz TA, Thomas LR, Payne WG, Moore WJ, Stott GM, Kondo J, Inoue M, Coffey R, Tansey WP, Stauffer S, Lee T, Fesik SW.
   Discovery and Structure-Based Optimization of Potent and Selective WD repeat domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core. J Med Chem. 2019 Dec 20. [Epub ahead of print]
10. Kondo J, Inoue M.
    Application of Cancer Organoid Model for Drug Screening and Personalized Therapy.(Review) Cells 2019, 8(5), 470; https://doi.org/10.3390/cells8050470
11. Kondo J, Ekawa T, Endo H, Yamazaki K, Tanaka N, Kukita Y, Okuyama H, Okami J, Imamura F, Ohue M, Kato K, Nomura T, Kohara A, Mori S, Dan S, Inoue M.
    High-throughput screening in colorectal cancer tissue-originated spheroids. Cancer Sci. 2019 Jan;110(1):345-355. doi: 10.1111/cas.13843.
12. Piulats JM*, Kondo J*, Endo H, Ono H, Hagihara T, Okuyama H, Nishizawa Y, Tomita Y, Ohue M, Okita K, Oyama H, Bono H, Masuko T, Inoue M. (* co-first authors)
    Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer. Oncotarget. 2018; Mar 23;9(22):15968-15983.
13. Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC.
    Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat Med. 2018 Feb;24(2):194-202.
14. Short SP*, Kondo J*, Smalley-Freed WG, Takeda H, Dohn MR, Powell AE, Carnahan RH, Washington MK, Tripathi M, Payne DM, Jenkins NA, Copeland NG, Coffey RJ, Reynolds AB. (* co-first authors)
    p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia. J Clin Invest. 2017 Dec 1;127(12):4462-4476.
15. Kim SW, Ehrman J, Ahn MR, Kondo J, Lopez AAM, Oh YS, Kim XH, Crawley SW, Goldenring JR, Tyska MJ, Rericha EC, Lau KS.
    Shear stress induces noncanonical autophagy in intestinal epithelial monolayers. Mol Biol Cell. 2017 Nov 1;28(22):3043-3056.
16. Okuyama H, Kondo J, Sato Y, Endo H, Nakajima A, Piulats JM, Tomita Y, Fujiwara T, Itoh Y, Mizoguchi A, Ohue M, Inoue M.
    Dynamic Change of Polarity in Primary Cultured Spheroids of Human Colorectal Adenocarcinoma and Its Role in Metastasis. Am J Pathol. 2016;186(4):899-911.
17. Hayashi Y, Tsujii M, Kodama T, Akasaka T, Kondo J, Hikita H, Inoue T, Tsujii Y, Maekawa A, Yoshii S, Shinzaki S, Watabe K, Tomita Y, Inoue M, Tatsumi T, Iijima H, Takehara T.
    p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth. Carcinogenesis. 2016 Oct;37(10):972-984.
18. Kondo J, Powell AE, Wang Y, Musser MA, Southard-Smith EM, Franklin JL, Coffey RJ.
    LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice. Gastroenterology. 2015 Aug;149(2):407-19.e8.
19. Ying J, Tsujii M, Kondo J, Hayashi Y, Kato M, Akasaka T, Inoue T, Shiraishi E, Inoue T, Hiyama S, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
    The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells. Int J Oncol. 2015 Apr;46(4):1551-9.
20. Akasaka T, Tsujii M, Kondo J, Hayashi Y, Ying J, Lu Y, Kato M, Yamada T, Yamamoto S, Inoue T, Tsujii Y, Maekawa A, Fujinaga T, Shiraishi E, Hiyama S, Inoue T, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
    5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells. Int J Oncol. 2015 Jan;46(1):63-70.
21. Mukai A, Iijima H, Hiyama S, Fujii H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Hayashi Y, Kondo J, Mizushima T, Kanto T, Egawa S, Nishida T, Tsujii M, Takehara T.
    Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease. J Gastroenterol. 2014 Dec;49(12):1524-35.
22. Inoue T, Nishida T, Maekawa A, Tsujii Y, Akasaka T, Kato M, Hayashi Y, Yamamoto S, Kondo J, Yamada T, Shinzaki S, Iijima H, Tsujii M, Takehara T.
    10. Clinical features of post-polypectomy bleeding associated with heparin bridge therapy. Dig Endosc. 2014 Mar;26(2):243-9.
23. Endo H, Okami J, Okuyama H, Kumagai T, Uchida J, Kondo J, Takehara T, Nishizawa Y, Imamura F, Higashiyama M, Inoue M.
    Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation. J Thorac Oncol. 2013;8(2):131-9.
24. Hayashi Y, Tsujii M, Wang J, Kondo J, Akasaka T, Jin Y, Li W, Nakamura T, Nishida T, Iijima H, Tsuji S, Kawano S, Hayashi N, Takehara T.
    CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis. Gut. 2013 Nov;62(11):1536-46.
25. Tsujii Y, Nishida T, Kato M, Inoue T, Yamamoto S, Hayashi Y, Akasaka T, Kondo J, Yamada T, Shinzaki S, Iijima H, Tsujii M, Takehara T.
    Mucosa-associated lymphoid tissue (MALT) lymphoma of the esophagus. Dis Esophagus. 2013 Apr;26(3):349-50.
26. Yamamoto S, Nishida T, Kato M, Inoue T, Hayashi Y, Kondo J, Akasaka T, Yamada T, Shinzaki S, Iijima H, Tsujii M, Takehara T.
    Evaluation of endoscopic ultrasound image quality is necessary in endosonographic assessment of early gastric cancer invasion depth. Gastroenterol Res Pract. 2012;2012:194530.
27. Yamamoto S, Nishida T, Tsujii M, Kato M, Hayashi Y, Kondo J, Inoue T, Akasaka T, Yamada T, Watabe K, Takehara T.
    Epstein-Barr virus-associated early gastric cancer presenting as an elevated lesion. Endoscopy. 2012;44 Suppl 2 UCTN:E222-3.
28. Kondo J, Endo H, Okuyama H, Ishikawa O, Iishi H, Tsujii M, Ohue M, Inoue M.
    Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer. Proc Natl Acad Sci U S A. 2011;108(15):6235-40.
29. Nakajima S, Iijima H, Egawa S, Shinzaki S, Kondo J, Inoue T, Hayashi Y, Ying J, Mukai A, Akasaka T, Nishida T, Kanto T, Tsujii M, Hayashi N.
    Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nutrition. 2011 Oct;27(10):1023-8.
30. Nakajima S, Iijima H, Shinzaki S, Egawa S, Inoue T, Mukai A, Hayashi Y, Kondo J, Akasaka T, Nishida T, Kanto T, Morii E, Mizushima T, Miyoshi E, Tsujii M, Hayashi N.
    Functional analysis of agalactosyl IgG in inflammatory bowel disease patients.Inflamm Bowel Dis. 2011 Apr;17(4):927-36.
31. Kondo J, Iijima H, Abe T, Komori M, Hiyama S, Ito T, Nakama A, Tominaga K, Kubo M, Suzuki K, Iwanaga Y, Ebara R, Takeda A, Tsuji S, Nishida T, Tsutsui S, Tsujii M, Hayashi N.
    Roles of double-balloon endoscopy in the diagnosis and treatment of Crohn's disease: a multicenter experience. J Gastroenterol. 2010 Jul;45(7):713-20.
32. Egawa S, Iijima H, Shinzaki S, Nakajima S, Wang J, Kondo J, Ishii S, Yoshio T, Irie T, Nishida T, Kakiuchi Y, Yasumaru M, Yoshihara H, Kanto T, Tsujii M, Tsuji S, Hayashi N.
    Upregulation of GRAIL is associated with remission of ulcerative colitis.Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G163-G169.
33. Kondo Y, Kondoh J, Hayashi D, Ban T, Takagi M, Kamei Y, Tsuji L, Kim J, Yoneda Y.
    21. Molecular cloning of one isotype of human lamina-associated polypeptide 1s and a topological analysis using its deletion mutants.Biochem Biophys Res Commun. 2002 Jun 21;294(4):770-8.
34. Kuwahara Y, Kondoh J, Tatara K, Azuma E, Nakajima T, Hashimoto M, Komachi Y.
    Involvement of urban living environments in atopy and enhanced eosinophil activity: potential risk factors of airway allergic symptoms.Allergy. 2001 Mar;56(3):224-30.