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Masahiro Inoue

　　

Contact information
Lab・Department of Clinical Bio-resource Research and Development
Kyoto University Graduate School of Medicine
  Med-Pharm Collaboration Bldg 503
  Shimoadachi-cho 46, Sakyou-ku, Kyoto, 606-8304, Japan
TEL・・1-75-752-7512
FAX・・1-75-752-7513
E-mail・masa_inoue@kuhp.kyoto-u.ac.jp



EDUCATION

1981-1987Osaka University Medical School
1991-1995Graduate school of Osaka University Medical School

PROFESSIONAL EXPERIENCE

1987-1991Clinical training in surgery and paediatric surgery
1995-1998Medial staff, Hospital of Osaka University Medical School
1998-2001Postdoctoral fellow, UC San Francisco
2001-2018Director, Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases
2011-presentProfessor, Graduate School of Pharmaceutical Sciences, Osaka University
2013-presentProfessor, Graduate School of Medicine, Kyoto University
2015-presentProfessor, Graduate School of Medicine, Osaka University
2018-presentProgram Specific Professor, Graduate School of Medicine, Kyoto University

RESEARCH FIELD

Primary culture of cancer cells, Tumor hypoxia, Angiogenesis


REFERENCE

  1. Lin YK, Coppo R, Onuma K, Endo H, Kondo J, Iwabuchi S, Hashimoto S, Itatani Y, Obama K, Inoue M. Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment. Cancer Sci. 19 September 2024 https://doi.org/10.1111/cas.16299
  2. Tabata S, Endo H, Makinoshima H, Soga T, Inoue M. The γ-glutamyl cycle serves as an amino acids supply system in colorectal cancer organoids under chronic hypoxia Biochem Biophys Res Commun. 2024 Jun 25:714:149977. 2024 Apr. https://doi.org/10.1016/j.bbrc.2024.149977
  3. Masuda M, Iida K, Iwabuchi S, Tanaka M, Kubota S, Uematsu H, Onuma K, Kukita Y, Kato K, Kamiura S, Nakajima A, Coppo R, Kanda M, Yoshino K, Ueda Y, Morii E, Kimura T, Kondo J, Okada-Hatakeyama M, Shinichi Hashimoto S, Masahiro Inoue M
  4. Suezawa T, Sasaki N, Yukawa Y, Assan N, Uetake Y, Onuma K, Kamada R, Tomioka D, Sakurai H, Katayama R, Inoue M, & Matsusaki M. Ultra-Rapid and Specific Gelation of Collagen Molecules for Transparent and Tough Gels by Transition Metal Complexation. Adv Sci (Weinh). 11 Sep 2023 https://doi.org/10.1002/advs.202302637
  5. Uematsu H, Saito C, Kondo J, Onuma K, Coppo R, Mori Y, Muto M, Kikawa Y, Tada M, Sugie T & Inoue M De-differentiation in cultures of organoids from luminal-type breast cancer is restored by inhibition of NOTCH signaling Human Cell. 27 Aug 2023 https://doi.org/10.1007/s13577-023-00975-7
  6. Coppo R, Kondo J, Onuma K, Inoue M Tracking the growth fate of single cells and isolating slow-growing cells in human colorectal cancer organoids STAR Protocols. 28 June 2023 https://doi.org/10.1016/j.xpro.2023.102395
  7. Shimizu S, Kondo J, Onuma K, Coppo R, Ota K, Kamada M, Harada Y, Tanaka Y, Nakazawa M, Tamada Y, Okuno Y, Kawada K, Obama K, Coffey RJ, Fujiwara Y, Inoue M Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK-dependent colorectal cancer Cancer Science. 25 June 2023 https://doi.org/10.1111/cas.15882
  8. Nashimoto Y, Shishido S, Onuma K, Ino K, Inoue M and Shiku H Oxygen metabolism analysis of a single organoid for non-invasive discrimination of cancer subpopulations with different growth capabilities Front. Bioeng. Biotechnol. 2023 May. https://doi.org/10.3389/fbioe.2023.1184325
  9. Katsuhiro Tomofuji , Jumpei Kondo, Kunishige Onuma, Roberto Coppo, Hiroshi Horie , Koki Oyama, Eiji Miyoshi, Ken Fukumitsu, Takamichi Ishii , Etsuro Hatano , Masahiro Inoue Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors Hepatol Commun. 2023 Apr. https://doi.org/10.1097/hc9.0000000000000134
  10. Roberto Coppo, Jumpei　Kondo, Keita　Iida, Mariko Okada, Kunishige Onuma, Yoshihisa Tanaka, Mayumi Kamada, Masayuki Ohue, Kenji Kawada, Kazutaka Obama, Masahiro Inoue. Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity iScience. 2023 Feb. https://doi.org/10.1016/j.isci.2023.105962
  11. Yu Ito, Jumpei Kondo, Masamune Masuda, Shinya Matsuzaki, Kunishige Onuma, Mizuki Kanda, Yuko Watanabe, Hitomi Sakaguchi, Kiyoshi Yoshino, Yutaka Ueda, Shoji Kamiura, Tadashi Kimura & Masahiro Inoue Ex vivo chemosensitivity assay using primary ovarian cancer organoids for predicting clinical response and screening effective drugs Human Cell. 2022 Dec. https://doi.org/10.1007/s13577-022-00827-w
  12. Tomofuji K, Fukumitsu K, Kondo J, Horie H, Makino K, Wakama S, Ito T, Oshima Y, Ogiso S, Ishii T, Inoue M, Hatano E Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts Biomaterials. 2022 Jun 1;287:121614. https://doi.org/10.1016/j.biomaterials.2022.121614
  13. Kawata M, Kondo J, Onuma K, Ito Y, Yokoi T, Hamanishi J, Mandai M, Kimura T, Inoue M Polarity switching of ovarian cancer cell clusters via SRC family kinase is involved in the peritoneal dissemination Cancer Sci. 2022 Oct;113(10):3437-3448. https://doi.org/10.1111/cas.15493
  14. Fukuoka T, Moriwaki K, Takamatsu S, Kondo J, Tanaka-Okamoto M, Tomioka A, Semba M, Komazawa-Sakon S, Kamada Y, Kaji H, Miyamoto Y, Inoue M, Bessho K, Miyoshi Y, Ozono K, Nakano H, Miyoshi E Lewis glycosphingolipids as critical determinants of TRAIL sensitivity in cancer cells Oncogene. 2022 Aug 4;38(18):4330-6. https://doi.org/10.1038/s41388-022-02434-3
  15. Iida K, Kondo J, Wibisana JN, Inoue M, Okada M Functional annotation-driven unsupervised clustering of single-cell transcriptomes Bioinformatics. 2022 Sep;41(38):4385-4396. https://doi.org/10.1093/bioinformatics/btac541
  16. Onuma K, Inoue M Abnormality of apico-basal polarity in adenocarcinoma Cancer Sci. 2022 Sep 1. doi: 10.1111/cas.15549.
  17. Nashimoto Y, Mukomotoc R, Imaizumic T, Terai T, Shishido S, Ino K, Yokokawa R, Miura T, Onuma K, Inoue M, Shiku H Electrochemical sensing of oxygen metabolism for a three-dimensional cultured model with biomimetic vascular flow Biosensors and Bioelectronics 2023 Jan 219;1:114808 https://doi.org/10.1016/j.bios.2022.114808
  18. Onuma K, Sato Y, Okuyama H, Uematsu H, Homma K, Ohue M, Kondo J, Inoue M Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma J Pathol. 2021 Jun 22. doi: 10.1002/path.5748.
  19. Tanaka M, Kondo J, Kaneko K, Endo H, Onuma K, Coppo R, Masuda M, Kamiura S, Yoshino K, Ueda Y, Kakeya H, Kimura T, Inoue M Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix Hum Cell. 2021 May;34(3):889-900.
  20. Endo H, Kondo J, Onuma K, Ohue M, Inoue M A small subset of Wnt‐activated cells is an initiator of regrowth in colorectal cancer organoids after irradiation Cancer Sci. First published: 11 October 2020
  21. Banda M, McKim K, Myers M, Inoue M, Parsons B Outgrowth of erlotinib-resistant subpopulations recapitulated in patient-derived lung tumor spheroids and organoids Plos One 2020 Sep 8; 15(9): e0238862.
  22. Arita T, Kondo J, Kaneko Y, Tsutsumi M, Kanemaru M, Matsui M, Arakawa Y, Katoh N, Inoue M, Asai J Novel ex vivo disease model for extramammary Paget's disease using the cancer tissue-originated spheroid method J Dermatol Sci 2020 Aug 5;S0923-1811(20)30237-1.
  23. Kubota S, Tanaka M, Endo H, Ito Y, Onume K, Ueda Y, Mikura S, Yoshino K, Kimura T, Kondo J, Inoue M. Dedifferentiation of neuroendocrine carcinoma of the uterine cervix in hypoxia BBRC. 2020 Jan 30, 9 [epub ahead of print]
  24. Okita K, Okazaki S, Uejima S, Yamada E, Kaminaka H, Kondo M, Ueda S, Tokiwa R, Iwata N, Yamasaki A, Hayashi N, Ogura D, Hirotani K, Yoshioka T, Inoue M, Masuko K, Masuko T. Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers. Oncotarget 2020 Jan 7;11(1):31-45.
  25. Ideo H, Kondo J, Nomura T, Nonomura N, Inoue M, Amano J Study of glycosylation of prostate-specific antigen secreted by cancer tissue-originated spheroids reveals new candidates for prostate cancer detection Sci Rep. 2020 Feb 17;10, Article number: 2708
  26. Hagihara T, Kondo J, Endo H, Ohue M, Sakai Y, Inoue M. Hydrodynamic stress stimulates growth of cell clusters via the ANXA1/PI3K/AKT axis in colorectal cancer Sci Rep. 2019 Dec 27, 9, Article number: 20027
  27. Tian J, Teuscher K, Aho ER, Alvarado JR, Mills JJ, Meyers KM, Gogliotti RD, Han C, Macdonald JD, Sai J, Shaw JG, Sensintaffar JL, Zhao B, Rietz TA, Thomas LR, Payne WG, Moore WJ, Stott GM, Kondo J, Inoue M, Coffey R, Tansey WP, Stauffer S, Lee T, Fesik SW.
    Discovery and Structure-Based Optimization of Potent and Selective WD repeat domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core. J Med Chem. 2019 Dec 20. [Epub ahead of print]
  28. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019 Aug 13;28(7):1860-1878.e9. doi: 10.1016/j.celrep.2019.07.027.
  29. Kondo J, Inoue M. Application of Cancer Organoid Model for Drug Screening and Personalized Therapy.(Review) Cells 2019, 8(5), 470; https://doi.org/10.3390/cells8050470
  30. Endo H, Inoue M. Dormancy in cancer. (Reiew) Cancer Sci. 2019 Feb;110(2):474-480.
  31. Kondo J, Ekawa T, Endo H, Yamazaki K, Tanaka N, Kukita Y, Okuyama H, Okami J, Imamura F, Ohue M, Kato K, Nomura T, Kohara A, Mori S, Dan S, Inoue M. High-throughput screening in colorectal cancer tissue-originated spheroids. Cancer Sci. 2019 Jan;110(1):345-355.
  32. Egawa-Takata T, Yoshino K, Hiramatsu K, Nakagawa S, Serada S, Nakajima A, Endo H, Kubota S, Matsuzaki S, Kobayashi E, Ueda Y, Morii E, Inoue M, Naka T, Kimura T. Small Cell Carcinomas of the Uterine Cervix and Lung: Proteomics Reveals Similar Protein Expression Profiles. Int J Gynecol Cancer. 2018 Nov;28(9):1751-1757.2018
  33. Piulats JM, Kondo J, Endo H, Ono H, Hagihara T, Okuyama H, Nishizawa Y, Tomita Y, Ohue M, Okita K, Oyama H, Bono H, Masuko T, Inoue M. Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer. Oncotarget. 2018; Mar 23;9(22):15968-15983.
  34. Kunimasa K, Isei T, Nakamura H, Kimura M, Inoue T, Tamiya M, Nishino K, Kumagai T, Nakatsuka SI, Endo H, Inoue M, Imamura F. Proliferative CD8(+) PD-1(+) T-cell infiltration in a pembrolizumab-induced cutaneous adverse reaction. Invest New Drugs. 2018 Dec;36(6):1138-1142.
  35. Yoshida T, Okuyama H, Endo H, Inoue M. Spheroid Cultures of Primary Urothelial Cancer Cells: Cancer Tissue-Originated Spheroid (CTOS) Method. Methods Mol Biol. 2018;1655:145-153.
  36. Tashiro T, Okuyama H, Endo H, Kawada K, Ashida Y, Ohue M, Sakai Y, Inoue M. In vivo and ex vivo cetuximab sensitivity assay using three-dimensional primary culture system to stratify KRAS mutant colorectal cancer. PLoS One. 2017 Mar 16;12(3):e0174151.
  37. Hara T, Nakaoka HJ, Hayashi T, Mimura K, Hoshino D, Inoue M, Nagamura F, Murakami Y, Seiki M, Sakamoto T. Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes. Proc Natl Acad Sci USA.2017 May 30;114(22):E4416-E4424.
  38. Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K. Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase. J Biol Chem 2017 May 26;292(21):8716-8728.
  39. Tanaka M, Kataoka H, Yano S, Sawada T, Akashi H, Inoue M, Suzuki S, Inagaki Y, Hayashi N, Nishie H, Shimura T, Mizoshita T, Mori Y, Kubota E, Tanida S, Takahashi S, Joh T. Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin). Oncotarget. 2016;7(30):47242-47251.
  40. Sato Y, Tateno H, Adachi J, Okuyama H, Endo H, Tomonaga T, Inoue M. Generation of a monoclonal antibody recognizing the CEACAM glycan structure and inhibiting adhesion using cancer tissue-originated spheroid as an antigen. Sci Rep. 2016;6:24823.
  41. Okuyama H, Kondo J, Sato Y, Endo H, Nakajima A, Piulats JM, Tomita Y, Fujiwara T, Itoh Y, Mizoguchi A, Ohue M, Inoue M. Dynamic Change of Polarity in Primary Cultured Spheroids of Human Colorectal Adenocarcinoma and Its Role in Metastasis. Am J Pathol. 2016;186(4):899-911.
  42. Narumi A, Tsuji T, Shinohara K, Yamazaki H, Kikuchi M, Kawaguchi S, Mae T, Ikeda A, Sakai Y, Kataoka H, Inoue M, Nomoto A, Kikuchi J, Yano S. Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility. Org Biomol Chem. 2016;14(14):3608-13.
  43. Kiyohara Y, Yoshino K, Kubota S, Okuyama H, Endo H, Ueda Y, Kimura T, Kimura T, Kamiura S, Inoue M. Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer. Cancer Sci. 2016;107(4):452-60.
  44. Kimura H, Fumoto K, Shojima K, Nojima S, Osugi Y, Tomihara H, Eguchi H, Shintani Y, Endo H, Inoue M, Doki Y, Okumura M, Morii E, Kikuchi A. CKAP4 is a Dickkopf1 receptor and is involved in tumor progression. J Clin Invest. 2016;126(7):2689-705.
  45. Hiraide T, Ikegami K, Sakaguchi T, Morita Y, Hayasaka T, Masaki N, Waki M, Sugiyama E, Shinriki S, Takeda M, Shibasaki Y, Miyazaki S, Kikuchi H, Okuyama H, Inoue M, Setou M, Konno H. Accumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer. Sci Rep. 2016;6:29935.
  46. Hayashi N, Kataoka H, Yano S, Kikuchi J-I, Tanaka M, Nishie H, Kinoshita Y, Hatano M, Nomoto A, Ogawa A, Inoue M, Mizoshita T, Shimura T, Mori Y, Kubota E, Tanida S, Joh T. Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric Cancer. Anticancer Research. 2016;36(11):6005-10.
  47. Arai M, Kawachi T, Kotoku N, Nakata C, Kamada H, Tsunoda S, Tsutsumi Y, Endo H, Inoue M, Sato H, Kobayashi M. Furospinosulin-1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia-Adapted Cancer Cells by Binding to Transcriptional Regulators p54(nrb) and LEDGF/p75. Chembiochem. 2016;17(2):181-9.
  48. Yuan Q, Furukawa T, Tashiro T, Okita K, Jin ZH, Aung W, Sugyo A, Nagatsu K, Endo H, Tsuji AB, Zhang MR, Masuko T, Inoue M, Fujibayashi Y, Saga T. Immuno-PET Imaging of HER3 in a Model in which HER3 Signaling Plays a Critical Role. PLoS One. 2015;10(11):e0143076.
  49. Yoshii Y, Furukawa T, Waki A, Okuyama H, Inoue M, Itoh M, Zhang MR, Wakizaka H, Sogawa C, Kiyono Y, Yoshii H, Fujibayashi Y, Saga T. High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment. Biomaterials. 2015;51:278-89.
  50. Yoshida T, Okuyama H, Nakayama M, Endo H, Tomita Y, Nonomura N, Nishimura K, Inoue M. Dynamic Change in p63 Protein Expression during Implantation of Urothelial Cancer Clusters. Neoplasia. 2015;17(7):574-85.
  51. Yoshida T, Okuyama H, Nakayama M, Endo H, Nonomura N, Nishimura K, Inoue M. High-dose chemotherapeutics of intravesical chemotherapy rapidly induce mitochondrial dysfunction in bladder cancer-derived spheroids. Cancer Sci. 2015;106(1):69-77.
  52. Yano S, Naemura M, Toshimitsu A, Akiyama M, Ikeda A, Kikuchi JI, Shen X, Duan Q, Narumi A, Inoue M, Ohkubo K, Fukuzumi S. Efficient singlet oxygen generation from sugar pendant C derivatives for photodynamic therapy. Chem Commun (Camb). 2015.
  53. Nakajima A, Endo H, Okuyama H, Kiyohara Y, Kimura T, Kamiura S, Hiraoka M, Inoue M. Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix. Int J Cancer. 2015;136(12):2949-60.
  54. Motoori M, Yano M, Tanaka K, Kishi K, Takahashi H, Inoue M, Saito T, Sugimura K, Fujiwara Y, Ishikawa O, Sakon M. Intraoperative photodynamic diagnosis of lymph node metastasis in esophageal cancer patients using 5-aminolevulinic acid. Oncol Lett. 2015;10(5):3035-9.
  55. Mori Y, Takahashi N, Polat OK, Kurokawa T, Takeda N, Inoue M. Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation. Pflugers Arch. 2015.
  56. Lee SH, Hong JH, Park HK, Park JS, Kim BK, Lee JY, Jeong JY, Yoon GS, Inoue M, Choi GS, Lee IK. Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors. Cancer Lett. 2015.
  57. Kurokawa H, Ito H, Inoue M, Tabata K, Sato Y, Yamagata K, Kizaka-Kondoh S, Kadonosono T, Yano S, Inoue M, Kamachi T. High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime. Sci Rep. 2015;5:10657.
  58. Kimura M, Endo H, Inoue T, Nishino K, Uchida J, Kumagai T, Kukita Y, Kato K, Imamura F, Inoue M. Analysis of ERBB Ligand-Induced Resistance Mechanism to Crizotinib by Primary Culture of Lung Adenocarcinoma with EML4-ALK Fusion Gene. J Thorac Oncol. 2015;10(3):527-30.
  59. Furukawa T, Yuan Q, Jin ZH, Aung W, Yoshii Y, Hasegawa S, Endo H, Inoue M, Zhang MR, Fujibayashi Y, Saga T. A limited overlap between intratumoral distribution of 1-(5-fluoro-5-deoxy-alpha-D-arabinofuranosyl)-2-nitroimidazole and copper-diacetyl-bis[N(4)-methylthiosemicarbazone]. Oncol Rep. 2015;34(3):1379-87.
  60. Tanaka-Okamoto M, Itoh Y, Miyoshi J, Mizoguchi A, Mizutani K, Takai Y, Inoue M. Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium. PLoS One. 2014;9(10):e110549.
  61. Sato Y, Inoue M, Yoshizawa T, Yamagata K. Moderate hypoxia induces beta-cell dysfunction with HIF-1-independent gene expression changes. PLoS One. 2014;9(12):e114868.
  62. Iwamoto M, Kawada K, Nakamoto Y, Itatani Y, Inamoto S, Toda K, Kimura H, Sasazuki T, Shirasawa S, Okuyama H, Inoue M, Hasegawa S, Togashi K, Sakai Y. Regulation of 18F-FDG accumulation in colorectal cancer cells with mutated KRAS. J Nucl Med. 2014;55(12):2038-44.
  63. Furukawa T, Yuan Q, Jin ZH, Aung W, Yoshii Y, Hasegawa S, Endo H, Inoue M, Zhang MR, Fujibayashi Y, Saga T. Comparison of intratumoral FDG and Cu-ATSM distributions in cancer tissue originated spheroid (CTOS) xenografts, a tumor model retaining the original tumor properties. Nucl Med Biol. 2014.
  64. Endo H, Okuyama H, Ohue M, Inoue M. Dormancy of Cancer Cells with Suppression of AKT Activity Contributes to Survival in Chronic Hypoxia. PLoS One. 2014;9(6):e98858.
  65. Yamaki T, Suenaga Y, Iuchi T, Alagu J, Takatori A, Itami M, Araki A, Ohira M, Inoue M, Kageyama H, Yokoi S, Saeki N, Nakagawara A. Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma. Sci Rep. 2013;3:1160.
  66. Okuyama H, Yoshida T, Endo H, Nakayama M, Nonomura N, Nishimura K, Inoue M. Involvement of heregulin/HER3 in the primary culture of human urothelial cancer. J Urol. 2013;190(1):302-10.
  67. Endo H, Okami J, Okuyama H, Kumagai T, Uchida J, Kondo J, Takehara T, Nishizawa Y, Imamura F, Higashiyama M, Inoue M. Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation. J Thorac Oncol. 2013;8(2):131-9.
  68. Zheng X, Wang X, Ma Z, Gupta Sunkari V, Botusan I, Takeda T, Bjorklund A, Inoue M, Catrina SB, Brismar K, Poellinger L, Pereira TS. Acute hypoxia induces apoptosis of pancreatic beta-cell by activation of the unfolded protein response and upregulation of CHOP. Cell Death Dis. 2012;3:e322.
  69. Takeda T, Okuyama H, Nishizawa Y, Tomita S, Inoue M. Hypoxia inducible factor-1alpha is necessary for invasive phenotype in Vegf-deleted islet cell tumors. Sci Rep. 2012;2:494.
  70. Kishi K, Fujiwara Y, Yano M, Inoue M, Miyashiro I, Motoori M, Shingai T, Gotoh K, Takahashi H, Noura S, Yamada T, Ohue M, Ohigashi H, Ishikawa O. Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer. J Surg Oncol. 2012;106(3):294-8.
  71. Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, McKenna WG, Muschel RJ, Hiraoka M. Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat Commun. 2012;3:783.
  72. Xie L, Duncan MB, Pahler J, Sugimoto H, Martino M, Lively J, Mundel T, Soubasakos M, Rubin K, Takeda T, Inoue M, Lawler J, Hynes RO, Hanahan D, Kalluri R. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A. 2011;108(24):9939-44.
  73. Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M. Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro. J Biol Chem. 2011;286(14):12524-32.
  74. Nakamura H, Hori K, Tanaka-Okamoto M, Higashiyama M, Itoh Y, Inoue M, Morinaka S, Miyoshi H. Decreased Expression of LM07 and its clinicopathological significance in human lung adenocarcinoma. Exp ther med. 2011;2(6):1053-7.
  75. Kondo J, Endo H, Okuyama H, Ishikawa O, Iishi H, Tsujii M, Ohue M, Inoue M. Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer. Proc Natl Acad Sci U S A. 2011;108(15):6235-40.
  76. Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y, Murakami A, Tani T, Watanabe H, Tanaka T, Hirota K, Inoue M, Tsukamoto T, Toyoda T, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S. Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging. PLoS One. 2011;6(11):e26640.
  77. Okuyama H, Endo H, Akashika T, Kato K, Inoue M. Downregulation of c-MYC protein levels contributes to cancer cell survival under dual deficiency of oxygen and glucose. Cancer Res. 2010;70(24):10213-23.
  78. Kishi K, Yano M, Inoue M, Miyashiro I, Motoori M, Tanaka K, Goto K, Eguchi H, Noura S, Yamada T, Ohue M, Ohigashi H, Ishikawa O. Talaporfin-mediated photodynamic therapy for peritoneal metastasis of gastric cancer in an in vivo mouse model: drug distribution and efficacy studies. Int J Oncol. 2010;36(2):313-20.
  79. Egawa-Takata T, Endo H, Fujita M, Ueda Y, Miyatake T, Okuyama H, Yoshino K, Kamiura S, Enomoto T, Kimura T, Inoue M. Early reduction of glucose uptake after cisplatin treatment is a marker of cisplatin sensitivity in ovarian cancer. Cancer Sci. 2010;101(10):2171-8.
  80. Arai M, Kawachi T, Setiawan A, Kobayashi M. Hypoxia-selective growth inhibition of cancer cells by furospinosulin-1, a furanosesterterpene isolated from an Indonesian marine sponge. ChemMedChem. 2010;5(11):1919-26.
  81. Toyofuku Y, Uchida T, Nakayama S, Hirose T, Kawamori R, Fujitani Y, Inoue M, Watada H. Normal islet vascularization is dispensable for expansion of beta-cell mass in response to high-fat diet induced insulin resistance. Biochem Biophys Res Commun. 2009;383(3):303-7.
  82. Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, Inoue M, Bergers G, Hanahan D, Casanovas O. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009;15(3):220-31.
  83. Nakayama S, Uchida T, Choi JB, Fujitani Y, Ogihara T, Iwashita N, Azuma K, Mochizuki H, Hirose T, Kawamori R, Inoue M, Watada H. Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin. Diabetologia. 2009;52(1):115-24.
  84. Nishihara T, Baba M, Matsuda M, Inoue M, Nishizawa Y, Fukuhara A, Araki H, Kihara S, Funahashi T, Tamura S, Hayashi N, Iishi H, Shimomura I. Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. World J Gastroenterol. 2008;14(42):6473-80.
  85. Koga T, Endo H, Miyamoto Y, Mukai M, Akira S, Inoue M. IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions. Cancer Lett. 2008;268(1):82-8.
  86. Isohashi F, Endo H, Mukai M, Inoue T, Inoue M. Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions. Cancer Sci. 2008;99(12):2395-401.
  87. Horita Y, Ohashi K, Mukai M, Inoue M, Mizuno K. Suppression of the Invasive Capacity of Rat Ascites Hepatoma Cells by Knockdown of Slingshot or LIM Kinase. J Biol Chem. 2008;283(10):6013-21.
  88. Baba M, Inoue M, Itoh K, Nishizawa Y. Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem Biophys Res Commun. 2008;374(1):111-6.
  89. Zhou J, Hara K, Inoue M, Hamada S, Yasuda H, Moriyama H, Endo H, Hirota K, Yonezawa K, Nagata M, Yokono K. Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions. Kobe J Med Sci. 2007;53(6):283-96.
  90. Zeng L, Kizaka-Kondoh S, Itasaka S, Xie X, Inoue M, Tanimoto K, Shibuya K, Hiraoka M. Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions. Cancer Sci. 2007;98(9):1394-401.
  91. Uchiyama A, Mukai M, Fujiwara Y, Kobayashi S, Kawai N, Murofushi H, Inoue M, Enoki S, Tanaka Y, Niki T, Kobayashi T, Tigyi G, Murakami-Murofushi K. Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid. Biochim Biophys Acta. 2007;1771(1):103-12.
  92. Matsuda C, Ito T, Song J, Mizushima T, Tamagawa H, Kai Y, Hamanaka Y, Inoue M, Nishida T, Matsuda H, Sawa Y. Therapeutic effect of a new immunosuppressive agent, everolimus, on interleukin-10 gene-deficient mice with colitis. Clin Exp Immunol. 2007;148(2):348-59.
  93. Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, Ferrara N, Gerber H, Kawamori R, Inoue M, Watada H. Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia. 2007;50(2):380-9.
  94. Harada H, Kizaka-Kondoh S, Li G, Itasaka S, Shibuya K, Inoue M, Hiraoka M. Significance of HIF-1-active cells in angiogenesis and radioresistance. Oncogene. 2007;26(54):7508-16.
  95. Endo H, Murata K, Mukai M, Ishikawa O, Inoue M. Activation of insulin-like growth factor signaling induces apoptotic cell death under prolonged hypoxia by enhancing endoplasmic reticulum stress response. Cancer Res. 2007;67(17):8095-103.
  96. Mukai M, Endo H, Iwasaki T, Tatsuta M, Togawa A, Nakamura H, Inoue M. RhoC is essential for TGF-beta1-induced invasive capacity of rat ascites hepatoma cells. Biochem Biophys Res Commun. 2006;346(1):74-82.
  97. Kusama T, Mukai M, Tatsuta M, Nakamura H, Inoue M. Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho. Int J Oncol. 2006;29(1):217-23.
  98. Kusama T, Mukai M, Endo H, Ishikawa O, Tatsuta M, Nakamura H, Inoue M. Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis. Cancer Sci. 2006;97(9):848-53.
  99. Nakamura H, Mukai M, Komatsu K, Tanaka-Okamoto M, Itoh Y, Ishizaki H, Tatsuta M, Inoue M, Miyoshi J. Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells. Cancer Lett. 2005;220(1):95-9.
  100. Mukai M, Kusama T, Hamanaka Y, Koga T, Endo H, Tatsuta M, Inoue M. Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activation. Cancer Res. 2005;65(20):9121-5.
  101. Hamanaka Y, Mukai M, Shimamura M, Kitagawa T, Nishida T, Isohashi F, Ito T, Nishizawa Y, Tatsuta M, Matsuda H, Inoue M. Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia. Biochem Biophys Res Commun. 2005;330(1):318-26.
  102. Daniel D, Chiu C, Giraudo E, Inoue M, Mizzen LA, Chu NR, Hanahan D. CD4+ T cell-mediated antigen-specific immunotherapy in a mouse model of cervical cancer. Cancer Res. 2005;65(5):2018-25.
  103. Inoue M, Mukai M, Hamanaka Y, Tatsuta M, Hiraoka M, Kizaka-Kondoh S. Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascites. Int J Oncol. 2004;25(3):713-20.
  104. Giraudo E, Inoue M, Hanahan D. An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest. 2004;114(5):623-33.
  105. Ohashi K, Winarno H, Mukai M, Inoue M, Prana MS, Simanjuntak P, Shibuya H. Indonesian medicinal plants. XXV. Cancer cell invasion inhibitory effects of chemical constituents in the parasitic plant Scurrula atropurpurea (Loranthaceae). Chem Pharm Bull (Tokyo). 2003;51(3):343-5.
  106. Mukai M, Iwasaki T, Tatsuta M, Togawa A, Nakamura H, Murakami-Murofushi K, Kobayashi S, Imamura F, Inoue M. Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion. Int J Oncol. 2003;22(6):1247-56.
  107. Kusama T, Mukai M, Tatsuta M, Matsumoto Y, Nakamura H, Inoue M. Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor. Clin Exp Metastasis. 2003;20(6):561-7.
  108. Kusama T, Mukai M, Ayaki M, Imamura F, Tatsuta M, Matsumoto Y, Nakamura H, Inoue M. Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Int J Oncol. 2003;23(4):1173-8.
  109. Kizaka-Kondoh S, Inoue M, Harada H, Hiraoka M. Tumor hypoxia: A target for selective cancer therapy. Cancer Sci. 2003;94(12):1021-8.
  110. Hoffman JA, Giraudo E, Singh M, Zhang L, Inoue M, Porkka K, Hanahan D, Ruoslahti E. Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma. Cancer Cell. 2003;4(5):383-91.
  111. Mukai M, Togawa A, Imamura F, Iwasaki T, Ayaki M, Mammoto T, Nakamura H, Tatsuta M, Inoue M. Sustained tyrosine-phosphorylation of FAK through Rho-dependent adhesion to fibronectin is essential for cancer cell migration. Anticancer Res. 2002;22(6A):3175-84.
  112. Kusama T, Mukai M, Iwasaki T, Tatsuta M, Matsumoto Y, Akedo H, Inoue M, Nakamura H. 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Gastroenterology. 2002;122(2):308-17.
  113. Kusafuka T, Kuroda S, Inoue M, Ara T, Yoneda A, Oue T, Udatsu Y, Osugi Y, Okada A. P53 gene mutations in pleuropulmonary blastomas. Pediatr Hematol Oncol. 2002;19(2):117-28.
  114. Komatsu K, Murata K, Kameyama M, Ayaki M, Mukai M, Ishiguro S, Miyoshi J, Tatsuta M, Inoue M, Nakamura H. Expression of S100A6 and S100A4 in matched samples of human colorectal mucosa, primary colorectal adenocarcinomas and liver metastases. Oncology. 2002;63(2):192-200.
  115. Inoue M, Hager JH, Ferrara N, Gerber HP, Hanahan D. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell. 2002;1(2):193-202.
  116. Inoue M, Hasegawa T, Kusafuka T, Sasaki T, Fukui Y, Okada A. Effective percutaneous transhepatic biliary drainage for cystic dilatation of the intrahepatic biliary system in biliary atresia: a case report. Eur J Pediatr Surg. 2000;10(6):395-7.
  117. Ara T, Kusafuka T, Inoue M, Kuroda S, Fukuzawa M, Okada A. Determination of imbalance between MMP-2 and TIMP-2 in human neuroblastoma by reverse-transcription polymerase chain reaction and its correlation with tumor progression. J Pediatr Surg. 2000;35(3):432-7.
  118. Inoue M, Hosoda K, Imura K, Kamata S, Fukuzawa M, Nakao K, Okada A. Mutational analysis of the endothelin-B receptor gene in Japanese Hirschsprung's disease. J Pediatr Surg. 1998;33(8):1206-8.
  119. Ara T, Fukuzawa M, Kusafuka T, Komoto Y, Oue T, Inoue M, Okada A. Immunohistochemical expression of MMP-2, MMP-9, and TIMP-2 in neuroblastoma: association with tumor progression and clinical outcome. J Pediatr Surg. 1998;33(8):1272-8.
  120. Okada A, Usui N, Inoue M, Kawahara H, Kubota A, Imura K, Kamata S. Esophageal atresia in Osaka: a review of 39 years' experience. J Pediatr Surg. 1997;32(11):1570-4.
  121. Inoue M, Minami M, Matsumoto M, Kishimoto T, Akira S. The amino acid residues immediately carboxyl-terminal to the tyrosine phosphorylation site contribute to interleukin 6-specific activation of signal transducer and activator of transcription 3. J Biol Chem. 1997;272(14):9550-5.
  122. Hirabayashi H, Fujii Y, Sakaguchi M, Tanaka H, Yoon HE, Komoto Y, Inoue M, Miyoshi S, Matsuda H. p16INK4, pRB, p53 and cyclin D1 expression and hypermethylation of CDKN2 gene in thymoma and thymic carcinoma. Int J Cancer. 1997;73(5):639-44.
  123. Hatada I, Nabetani A, Morisaki H, Xin Z, Ohishi S, Tonoki H, Niikawa N, Inoue M, Komoto Y, Okada A, Steichen E, Ohashi H, Fukushima Y, Nakayama M, Mukai T. New p57KIP2 mutations in Beckwith-Wiedemann syndrome. Hum Genet. 1997;100(5-6):681-3.
  124. Chen K, Nezu R, Inoue M, Wasa M, Iiboshi Y, Fukuzawa M, Kamata S, Takagi Y, Okada A. Beneficial effects of growth hormone combined with parenteral nutrition in the management of inflammatory bowel disease: an experimental study. Surgery. 1997;121(2):212-8.
  125. Chen K, Inoue M, Wasa M, Fukuzawa M, Kamata S, Okada A. Expression of endothelial constitutive nitric oxide synthase mRNA in gastrointestinal mucosa and its downregulation by endotoxin. Life Sci. 1997;61(13):1323-9.
  126. Shi W, Inoue M, Minami M, Takeda K, Matsumoto M, Matsuda Y, Kishimoto T, Akira S. The genomic structure and chromosomal localization of the mouse STAT3 gene. Int Immunol. 1996;8(8):1205-11.
  127. Minami M, Inoue M, Wei S, Takeda K, Matsumoto M, Kishimoto T, Akira S. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A. 1996;93(9):3963-6.
  128. Kamiike W, Taniguchi E, Iwase K, Ito T, Nezu R, Nishida T, Inoue M, Ohashi S, Matsuda H. Intraoperative manometry during laparoscopic operation for esophageal achalasia: does pneumoperitoneum affect manometry? World J Surg. 1996;20(8):973-6; discussion 6-7.
  129. Hatada I, Ohashi H, Fukushima Y, Kaneko Y, Inoue M, Komoto Y, Okada A, Ohishi S, Nabetani A, Morisaki H, Nakayama M, Niikawa N, Mukai T. An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome. Nat Genet. 1996;14(2):171-3.
  130. Chen K, Inoue M, Okada A. Expression of inducible nitric oxide synthase mRNA in rat digestive tissues after endotoxin and its role in intestinal mucosal injury. Biochem Biophys Res Commun. 1996;224(3):703-8.
  131. Usui N, Kamata S, Ishikawa S, Okuyama H, Wasa M, Inoue M, Okada A. Bronchial reconstruction for bronchopulmonary foregut malformation: a case report. J Pediatr Surg. 1995;30(10):1495-7.
  132. Taniguchi E, Kamiike W, Iwase K, Nishida T, Miyata M, Inoue M, Ohashi S, Okada T, Matsuda H. Laparoscopic extramucosal myectomy with anterior fundoplication (Dor) for esophageal achalasia using intraoperative manometry. Surg Endosc. 1995;9(7):817-9.
  133. Akira S, Nishio Y, Tanaka T, Inoue M, Matsusaka T, Wang XJ, Wei S, Yoshida N, Kishimoto T. Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway. Ann N Y Acad Sci. 1995;762:15-27; discussion -8.
  134. Inoue M, Kubota A, Hasegawa T, Hata S, Takahashi E, Kawahara H, Suehara N, Okada A. Antenatal diagnosis of sacrococcygeal teratoma with hydrops fetalis; a case report. Eur J Pediatr Surg. 1994;4(2):125-7.
  135. Hasegawa T, Imura K, Kubota A, Kobayashi T, Inoue M, Hata S, Shimizu I, Suehara N. Congenital diaphragmatic eventration detected by antenatal ultrasound: rationale for early operation. Pediatr Surg Int. 1994;9:405-6.
  136. Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell. 1994;77(1):63-71.
  137. Hasegawa T, Kubota A, Imura K, Kobayashi T, Inoue M, Hata S, Hosokawa S, Shimada K, Kanai T, Suehara N. neonatal caliceal diverticulum associated with hydronephrosis. Pediatr Surg Int. 1993;8:162-4.
  138. Hasegawa T, Kubota A, Imura K, Inoue M, Hata S, Kobayashi T, Kamiya H, Suehara N. Prenatal diagnosis of congenital pyloric atresia. J Clin Ultrasound. 1993;21(4):278-81.